NADP

Product Overview

Nicotinamide adenine dinucleotide phosphate (NADP) is the oxidized form of the NADP⁺/NADPH redox couple, which plays an important role in biological electron-transfer processes. Together, NADP⁺ and NADPH function as coenzymes in numerous oxidation-reduction reactions, supporting metabolic pathways and a wide range of biochemical research applications.

The NADP⁺/NADPH system participates in various enzyme-mediated reactions, including those associated with cytochrome P450 enzymes, oxidases, and reductases. It is also involved in biochemical pathways related to lipid and nucleic acid biosynthesis, as well as other cellular processes that require reducing equivalents.

NADP Disodium Salt is intended for laboratory and scientific research applications involving redox chemistry, enzyme systems, and metabolic studies.

Product Information

Synonyms

NADP Disodium Salt may also be identified by the following names:

• β-NADP-Na₂

• β-Nicotinamide adenine dinucleotide phosphate disodium salt

• β-NADP disodium salt

• Triphosphopyridine nucleotide disodium salt

The exact chemical identity and naming convention should be verified against the supplier's product documentation when ordering.

Biochemical Functions and Applications

Electron Transfer and Redox Reactions

The NADP⁺/NADPH coenzyme pair participates in electron-transfer reactions catalyzed by various enzymes. NADP⁺ serves as an electron acceptor in reduction reactions, while NADPH provides reducing equivalents in many biosynthetic and antioxidant-related pathways.

This reversible redox relationship makes the coenzyme pair useful for investigating enzyme activity, metabolic regulation, and biochemical reaction mechanisms.

Lipid and Nucleic Acid Biosynthesis

NADPH supplies reducing power for numerous anabolic processes. It is particularly relevant to lipid biosynthesis and contributes to the biochemical reactions required for the production of cellular components. NADP-related systems are therefore useful tools in studies of metabolism and biosynthetic pathways.

Cytochrome P450 Enzyme Systems

NADPH supports electron transfer in many cytochrome P450-dependent reactions through associated electron-transfer proteins and reductase systems. These pathways are studied in areas such as enzymology, biochemical transformation, and drug metabolism research.

Oxidoreductase and Thioredoxin Systems

NADPH is involved in several oxidoreductase pathways, including systems associated with thioredoxin reductase and thioredoxin. These systems contribute to cellular redox regulation and are frequently investigated in biochemical and molecular biology research.

Storage and Handling

To help maintain product quality, store NADP Disodium Salt under the specified refrigerated conditions of 2–8°C. Follow the supplier's handling instructions and consult the product documentation for additional requirements concerning moisture protection, preparation, and storage after opening.

Researchers should confirm the product's suitability for their experimental protocols and use appropriate laboratory handling procedures.

Research Use Only

NADP Disodium Salt is supplied for scientific research purposes only. It is intended for qualified laboratory applications and is not presented as a product for human or veterinary diagnostic, therapeutic, or food use.

References

1. Xiao, W., Wang, R.-S., Handy, D. E., and Loscalzo, J. “NAD(H) and NADP(H) Redox Couples and Cellular Energy Metabolism.” Antioxidants & Redox Signaling, 28(3), 2018.

2. Spaans, S. K., Weusthuis, R. A., van der Oost, J., and Kengen, S. W. “NADPH-generating systems in bacteria and archaea.” Frontiers in Microbiology, 6:742, 2015.